I have several friends who have had knee replacements (partial and full) and all have had good results if as goopysolelady says especially if you put in the hard PT work afterwards. One even recently went to India for a mountain trek. And a couple friends with Stage 3 prostrate cancer too. One had the radiation pellets and is doing great now; the other chose surgery and radiation and is okay from what we last heard. I hear there are new options available almost every month. Will keep you both in my thoughts over the coming months!