I second the Best Western St Jacobs. I haven't stayed there, but have been there for business meetings. A nice place, definitely a more upscale "hotel" feel. I live 5 min away from it - it is right on the edge of Waterloo. One minute down the road and you are in town, literally. The destination inn is just 3-4 minutes from this hotel, but as the last poster said it is a very busy area and doesn't appear as nice (box motel look). The road noise would be a lot higher too. You could walk from Destination to a Kelsey's, Quizno's or a Wendy's, whereas you would have to hop in the car from the Best Western, however it is truly just a few minutes to the same places.