Our last two trips have seen us staying in five different hotels . . . .
1st night of holiday Gatwick Hilton
1st & 2nd nights in Orlando Sheraton Safari hotel, nr Crossroads (Lake Buena Vista)
3rd 5th nights in Orlando Disneys Polynesian Resort
6th & 7th nights in Orlando Hard Rock Hotel
8th 18th nights Hilton, Marco Island
We stayed at the Sheraton Safari mainly because it had become a bit of an Osborne tradition we just needed somewhere as a base for the first couple of nights (first night of arrival and second day we went to Busch Gardens so didn't want to waste good money on a Disney or USF hotel when we wouldn't get much benefit).
We really like moving from hotel to hotel to give us the bases we want for the parks we want. We have also stayed at the AKL - fantastic, will definitely be back. We chose the Poly simply because the only Disney parks we wanted to visit were MK for
MNSSHP and Epcot, so given the monorail was there, the Poly was great. However, the rate I got $380 per night, was not so good and when I look back I still can't believe I actually paid over $1100 for three nights' in a hotel - but saying that it was a great experience.
We much prefer the Universal parks and we have stayed a few times now at the HRH. It is SO much better value for money - and dare I say it too, it's not got that "Disney in yer face" all the time
With the Universal Hotels, you feel you are getting value for money with their "onsite" perks - front of line access, virtually onsite for the parks and nightlife (well within walking distance or a nice little boatride). . . . we shall be staying at either the Portofino or Royal Pacific this summer to give them a try, but we won't be staying onsite at Disney since again we only want to visit a couple AK and MGM since as I've already said we're Universal park people

and we are only having 5 nights in Orlando - relaxing on the beach for two weeks beforehand this year in a friend's apartment nr Fort Myers beach, can't wait.
As you've seen from some of the replies to this thread, everyone has their own likes and dislikes. Personally, I agree that to spend more than a few days in a Disney hotel would not do for us - too much Disney . . . . and now we've been spoilt staying in the Deluxes, the prices for Disney really can be extortionate.