I say Atlanta or Savannah, GA. Atlanta has the World of Coke, the Aquarium, Underground Atlanta, Center for the Puppetry Arts, the Cyclorama and Zoo Atlanta. Lots of restaurants, Little 5 Points of you want to get a little funky, Buckhead, all kind of stuff. And for a Disney touch you can visit the Wren's Nest, Joel Chandler Harris' home (wrote the Uncle Remus tales) has memerobelia and a gift shop.
In Savannah you have all the historic homes, trolley tours, fort Pulaski, River front, and Tybee island nearby. There's a historic railroad exhibit, lots of good southern cooking, seafood, fine dining. We went for a weekend and stayed near the airport. I would definately reccomend staying somewhere in one of the squares in the historic district. You can walk to most everything or take the trolley. There are trolley stops everywhere. You can take a historic Savannah tour, explore the homes, take a ghost tour, pub tour, or just wander around. A funny note. We flew Airtran to Savannah from Atlanta. I was an Airtran employee at the time and wanted to take the girls for a short plane trip close enough to home to drive if they were really freaked out. The airport is so tiny. Clean, beautiful and small. The lady who checked us in on return gave us our boarding passes, took our luggage, loaded our luggage, helped the gate agent and FA's load the flight, used the orange thingeys to help the plane back up, and waved us goodbly. They literally had 5 or 6employees total, and only 3 working. It was unreal.
Have fun. Let us know what you decide!!