We go to San Diego often as youngest DD has been at the University of San Diego for the last four years. If you are looking for recommendations for hotels, let me know. Do you want to be on the beach, downtown, near Old Town or toward La Jolla?
We will be in San Diego from 5/25-30 for Sam's graduation. Our favorite hotel is the Del Coronado but we have stayed in many different hotels all over the San Diego area.
The Del Coronado looks amazing and I would just love to stay there, but not sure we can afford the prices. It will be top prices I imagine for Memorial Day weekend too! It is difficult to decide on an area when basically you want to see everything! I would love a sea/bay view, but they come at a premium too! But of course I will just have had 15 days of sea views!!

I saw your recommendation for rental properties on Mission Beach too.