Definitely a difference! The 2 br lockoff is a 1 br + a studio with an adjoining door - there are two entrances to the unit, a big kitchen in one, and a small fridge/microwave in the other, both rooms have king beds. The dedicated 2 bedroom has one entrance to the unit, and extra half bathroom near the entrance, one room has two queen beds and the other a king. We stayed in a dedicated 2 br in February and loved it.