We live in SW Michigan and drive down with our pop-up almost every spring break. The kids are now both in college so we will be going for the two weeks that they have off (2 colleges with different weeks) ... they will fly down to Orlando to stay with us. (This year will be about a month earlier than we usually go ... leaving on Feb 25th)
Anyway, we usually are all packed the night before including our ice chest and then will be on the road by 3:30 am. We stay at a hotel on the way down (and back). I have found that we have needed a reservation for a hotel because the good ones fill up fast and they are turning people away.
We make it down to Tifton (south of Macon) by 8:00 and stay at the Hampton Inn. It can be a bit pricey but I like a clean room, it has free breakfast, and they usually are situated so we don't have to worry about the camper in the lot.
This leaves us about 4-1/2 hours from Ft. Wilderness the next day.
On the way home, we try to be on the road by 6:00 am (Saturday) because we have gotten stuck in traffic exiting Florida!!! This puts us just a little ahead of the big crowd leaving the gulf area. We drive all day and stay at the Hampton Inn in Elizabethtown (south of Louisville), Kentucky -- getting there anywhere from 6:30-8:30 (depending on the traffic ... Nashville has had quite a bit of construction tie-ups the last two years). Then we have a 6+ hr drive back on Sunday.
We always make sure that we have access to food and drink and our stops are only for gas/potty/stretching of legs.
++++++++++
I would also agree that 5 days in the parks should be good. We will usually start out the day at one of the Early Entry parks, come back to the campsite for lunch and maybe a quick nap (depending on how late the parks are open) and then will take the boat to the MK to finish up the day. We have found that it is almost quicker to drive your own vehicle to all the parks except the MK, but that is a personal opinion and many people prefer the busses.
We have enjoyed the Kennedy Space Center and would recommend that with a follow-up trip to the ocean at Cocoa Beach (and, of course, Ron Jon's Surf Shop).
Another thing that we heard about from word of mouth and then did two years in a row was the "Old Fashioned Airboat Rides" from Christmas, FL. It takes about 45 minutes to get there (east of Orlando) and then you are only about 20 minutes from Cocoa Beach. We would get coupons off the internet and then call them and get a morning ride. We'd then drive into Cocoa Beach for a picnic at the public picnic area near Ron Jon's. Spend a couple hours at the beach and then a visit to Ron Jon's before heading back to Orlando.
Years ago we did Sea World and enjoyed that. We went to Universal before they had Islands of Adventure and were less than impressed. Probably because they aren't Disney, nor are they Cedar Point (Sandusky, OH ... World's #1 Amusement Park).
We tend to spend a lot of time just enjoying Ft. Wilderness and then filling in non-pool time by visiting the other WDW resorts. A visit to the other resorts is free ... you just can't use their facilities (i.e. pools). We will visit the gift shops, walk around the resorts, etc.
Another thing that is fun is BOB JACKSON who performs at the River Roost Lounge at Port Orleans Riverside. He plays the piano and has a very high-energy, family-oriented show. The show is FREE and since it's in a lounge you can order snacks and drinks. You'll want to check, but I think he just performs there on Wed-Saturday in the evenings.
You can take the boat from POR to Downtown Disney as well.
I'm sure you'll have a great time!!!