We have not done this with the Edit credit. However, we have done this with FN certs, where one is in my name under my account and the other is in P2s. We are planning to use the same strategy for stays next year with hotel credits from multiple Amex Plats, Citi Strata Elite, and Aspire cards, FN certs etc.
First we make sure that the same type of room is available for the night or two nights that will go under my credit and reservation. Then we make sure the exact same room type (bed, view, floor etc.) is also available for the one or 2 nights that go with P2s credit or reservation. For example, I would want one king size bed available and booked across all 4 nights. I would not want 2 nights booked in a room with a king bed and 2 nights booked in a room with 2 doubles or something. This leaves the opportunity to get notes on the reservation explaining that they should be considered linked and consecutive. Side note, I would not do this for an FHR/Hotel Collection reservation though, and instead just mention it at check in. So, at check in we explain to the front desk that we would like to stay in the same room across all 4 nights. We have had a 100% success rate so far and have never needed to switch rooms. Typically, we are asked to swing by the front desk the morning of check out for the first reservation and get re-keyed for the second reservation so we can get back in the room. It's a minor inconvenience but not a big deal.