THe other question is getting from said airport to the resort.
If you come into Sav/HHI here in SAvannah, you have three ways to get there. One you can take I-95 south to I-16, take the Savannah exit (not Macon) and just stay on the road over the big bridge (doesn't really have a name yet), take a right on SC 315 and go on to HHI.
If you go out the airport and take the right into Pt Wentworth, you can drive through the very nice Savannah River Wildlife Refuge (related to Pinckney Island), take a right on 170 and on to HHI.
Or the boring take I-95 North to 278, take the right at the exit and it's a straight shot from there to HHI. Quickest and boring.
No matter what, drive the speed limit while on the way (specially in Bluffton). It's not as bad a speed trap as it use to be, but, southern town...economy not as good as it use to be...get my drift? When I was a child, they were MUCH worse about it.
Your favorite map web site will give you directions no matter what way you want to go.