Ours is around 3000 square feet, including the finished basement. We have four bedrooms, 2 full baths and 2 half, LR, DR, kitchen and family room, basement gameroom, first floor laundry, 2 car garage. I do not think that we are "house poor" since our mortgage + taxes are less than 25% of our after-tax take-home income. There are things we would like to do with the house (omnistone patio, big screen TVs) that we can't "afford" right now but that is really due to choices -- we choose to save for retirement, go on vacation etc. instead.
Right now it is just the two of us plus our dog. We built our home in 2001 with the intention of filling it with children. We are currently working on our adoption application so hopefully it will be a little more "crowded" in the near future.
I will add also that it did take us awhile to decorate and furnish our home, but I don't see that as a bad thing. It was fun to take our time doing one room at a time and painting, picking out color schemes, finding exactly what we wanted.