Through Hotwire we stick with the "suites" hotels and have usually gotten one of the Amerisuites. Both are very nice properties.
With Priceline, I would only stick with the highest star level. The ones that are one level lower are mostly okay, but there is one SLUM LaQuinta (not to be confused with the LaQuinta Suites) that is a total dive and that you can get at that level. At the highest level, we've gotten the Marriott, Holiday Inn Select, and Renaissance, and all have been nice. They tend to put you in a connecting room when you are Priceline, but we're never heard any noise.
Barb