Most of the major hotel chains are represented in Valdosta. We've stayed at the Holiday Inn there (right by I-75) before and it was nice, though that was some five years ago. Things could have changed in those years, but I doubt it.
What I can personally recommend, from out experience just last summer and Christmas, are the Jameson Inn locations in Lake City, Florida (south of Valdosta) and Perry, Georgia (a couple hours north of Valdosta). Both a very nice, fairly new, and convenient locations for a decent price. I can say the same things about the Hampton Inn in Lake City from last summer, though this usually seems to be slightly more expensive than the Jameson. I believe there is also a Jameson in Valdosta, I just haven't personally stayed there.