I do the straight through drive all the time. From SE MA to Deltona, FL which is just about 1350 miles door to door. 18-22 hours on the road However, that's me. I would not give a 12 hour drive a second thought, I would just do it. After all, that is just a long driving shift for me at WDW.
I have done this with a 2 y/o and a 4 y/o twice. If they ride well and you have baggies of finger food and books/games available, that helps a lot. Nighttime driving is even better as they will sleep most of the trip.
There are many here that will not do that and that is their choice. Only you can decide if that is something that you can handle.
If you do, I suggest taking breaks to keep you fresh and if you have another driver, that makes straight through driving MUCH easier.
You may want to adjust your leave time to sometime early Sat morning, say like 3am. You will get some rest before leaving. Pack the car after work, go to bed early. This will get you in around 3pm, you can check in, grab a quick shower and be ready for your dinner. You won't have the normal weekday traffic to worry about.