There are two HD's in town, but I have to drive about 10 miles on the highway to get to Lowes, so Lowes loses.
In my opinion, Lowes tends to stray closer to the interior decorating aeshthetic (to get women to shop there) while HD is the more "manly" store. I found the prices for the things I am looking for to be about the same or cheaper at HD, especially factoring in the time and gas I'd waste goping to Lowes. And the Lowes closest to me has more clueless employees ("hey, assistant manager, what is a wire nut and [duh] do we sell them, b/c this lady wants to know or whatever?") that the two local HD's.