You can fly from wherever you want if you're willing to go indirect. Only Virgin fly direct from Manchester to Orlando. Depending on when you travel, flying indirect can also save you a great deal of money as you have a much wider choice of airlines.
Likewise, in Florida, you can fly home from the most convenient airport, particularly if you are willing to fly indirect. You need to know which airports you would prefer to use for your journey home and book an "open jaw" flight (arrives into one airport but departs from another - e.g. fly into Orlando International; depart from Fort Lauderdale).
Other than that, I'm not really sure what kind of "ideas" you are looking for - can you elaborate on what you would like help with?