Our kids are all teens and they still enjoy making things for their grandparents & aunts. Their crafts have gotten a little more challenging as they've grown. This year, they've made layered candles, handmade stamped card assortments (Thank you, Congrats, Happy Birthday, Thinking of You, etc.) and stamped, filled candy bags. The candle jars may be painted, if we have time.
In the past, they've painted on canvas carry totebags with handprints, stencil prints of ivy and the recipient's initials. When they were little, they put their handprints on throw pillows (pretty lace on one side, prints on the other) or made baked clay ornaments. We've bought inexpensive wooden plaques and painted "Grandma's kitchen" or something similar, then decorated with fitting buttons & trinkets to the recipients' style. Have fun!