Here's a short list:
Breakfast: Sun Rise Cafe, Skillets
Mexican: San Miguels, Mi Tierra's
Pizza: Giuseppi's, Del Vecchio's or the 30" pie at Monster Pizza (Bluffton)
Fish and Chips: Reilley's, British Open Pub
Seafood: Black Marlin, Alexander's, Redfish
Fun: One Hot Mama's, Capt Woody's, Salty Dog
A bit upscale: Stripes, Truffles, Tapas, Santa Fe, Jazz Corner
Up, up scale: HH Prime, Harbour Town Grill, Old Fort Pub, Trinity, May River Grill
Up, up, up scale: The Inn at Palmetto Bluff (Bluffton)
This can't be good but it's great!: Sunset Grille
Locals only: Up The Creek, Yummy House, The Fifth of May, Squat n' Gobble (Bluffton)