Northeast Ohio to Kissimmee...36 hours. We switch train in DC and have a long layover but we enjoy the trip. I'll touch on a few highlights ( tons of Amtrak reports, just do a search) coach the whole way is doable, sleepers are expensive and not really needed for one night (no sleepers keeps the cost reasonable). Food on the train is very good but pricey (pack a cooler with food, snacks and drinks). Don't pack anymore than you can personally haul, makes train travel easier. There's plenty of room in and around each pair of seats, they recline and have leg rests....take a blanket..gets cold at night from the A/C. Electronics are welcomed, some cars have a receptacle at each pair of seats and some cars have one for the whole car (Amtrak is up grading their cars so you never know what you'll encounter) headphones are required so as not to disturb others. That's it in a nut shell.
Trains can run late for a myriad of reasons, you never know but in the last couple of years, it's gotten alot better to keeping the schedule. They do make up time when they can but unforeseen events can and do occur. It won't be a day late, few minutes to hours at most but like I said, they are improving.
It would take us 20 hours to drive straight thru, done is years ago but the stress on my being, and the car are more than I care to experience anymore. We've taken our children many many years ago and they enjoyed it alot, seen the country, riding a train was the envy of their friends. Take games, books and things to occupy them. There's a club car where you can grab a seat and play, they serve drinks, and hand food and are priced fairly decent. Dining car is reservations, they'll come thru each car and ask if you're interested and give you a time. Restrooms (2) located at one end of each car (first come, unisex).
It is a long trip but easy to do, planning on what to entertain, nap time, bed time (lights out is 10 pm). A cooler with sandwiches and drinks can ease the time and pain of train travel. Some of the scenery is fantastic and some so-so but lying back, feet up, nestled is a blanket watching the scenery roll by is pure comforting, better than a car. Hope this helps and check out all the other train posts I've answered in the past. Need more, PM or ask me, always glad to help!