We flew out of K-W to Orlando, via Detroit, last August. It was pretty slick. You go through customs in Detroit (not in K-W). When we went, I was the only woman passenger on our flight to Detroit! Pretty nice ratio if you ask me!

Since the person doing the security check was also female, I was the lucky recipient of the only check on board! It was the most thorough check I've ever had. They were friendly though. Coming back from Detroit, however, there were many other females. There's just enough time on that flight for a drink. It's a smaller plane, so just be aware that you'll feel more bumps. It was no problem for me though.
Once in Detroit, you immediately go through customs. Pretty normal. Since your connection flight is so quick, you may want to ask where your gate is located. It's a large, beautiful airport so directions may be necessary, but people were friendly to help. We had a 2.5hr layover so we had time for lunch and to explore the beautiful airport. Of course, we went the day after the maintenance workers for NWA went on strike, so our flight was delayed for a few hours. That shouldn't happen for you though.
Have a great trip! Let me know if you have any more questions.