Orlando-Sanford International Airport is a decent choice for people who would rent a car anyway. You'd have a longer drive that if use Orlando International, but you might even recover some of that time because you'd be using a smaller, "faster" airport.
For people who don't rent cars anyway, Orlando-Sanford is not such good news. It's not served by Disney's Magical Express. Towncars and limos between Orlando-Sanford and WDW are much more expensive than between Orlando International and WDW. That makes sense when you consider that Orlando-Sanford is much further away.