We FLY!
It's a 20 - 24 hour drive (from the estimates I've heard others give from my neck of the woods). That means that round trip at least 3-4 days would be spent traveling (because you end up having to stop for bathroom breaks, some people stop in a hotel overnight on the way, etc.)
If it's just DH and I, I know that it won't cost us more than $400 RT total to fly. If DSD is with us, it isn't more than $600 total.
Time is money: I have paid vacation, and 3-4 days of paid vacation lost if we drove (the wage equivalent) is much much more money than $400-600. DH does not get paid vacation. His 3-4 days of lost wages if we drove would cost us much much more money than $400 - 600.
Before even considering the costs of gasoline, wear and tear on our vehicle, the money spent on food on the road, or possibly even a hotel room (if we had to stop overnight during the drive down or up), driving costs us several times more than flying!
Then, consider the wear and tear on our bodies from a drive like that. Vacation is getting a respite from driving (we both drive to commute, and anyone who lives in metro NYC area knows that commuting here is a PIA). If we need a car on vacation, we rent one. On vacation, we are supposed to be re-charging our bodies and minds, not taxing them.
To us, it is a very clear decision. We fly.