OOOH - your first time. That's so very cool. I remember my first time to WDW (I grew up in So Cal and practically lived at DL). It really is a fun and special time to be able to enjoy something so familiar - yet so different - from what you are accustomed to.
There are just so many things about DL to soak up and enjoy. Don't be surprised by what you will find inside the park - that at WDW you would find in multiple different parks. The sidewalks are narrower (think 1950's America), and the park is much more intimate in both scale and acreage.
Be sure to take a ride on the various Main Street vehicles. They truly are a fun part of the experience (and the run a lot longer during the day than the MK ones do).
Be sure to stop in to the Main Street Cinema and check out some classic Mickey moments - you can't get those in the MK anymore since they converted the cinema to a shop there. And check out the daily fresh candy being made in the Candy Parlor.
Definitely go through the Sleeping Beauty walk-thru of the castle. The entrance is just inside the castle courtyard to your left (as you go through the breezeway).
Pinocchio & Alice both have unique to DL adventures to enjoy. As does Mr. Toad, Casey Jr. and Roger Rabbit (up in Toontown).
Be sure to take a ride around Tom Sawyer Island in the Davy Crockett Explorer Canoes. Also be sure to ride the Sailing Ship Columbia, and while you do, explore below decks. It's a treat you definitely don't get in Florida.
While in New Orleans Square, stopy by the Mint Julep Bar at the back side of the French Market (near the train station) Mint Julep and some fritters. Or if you eat at the French Market, you can get a Mint Julep there too (non-alcoholic, of course).
In Adventureland you can enjoy Tarzan's Treehouse (similar but different than those Swiss castaways) and Indiana Jones Adventure (the imagineers used the exact same track layout when they later added Dinosaur to AK - but this theming is so much cooler), and you'll be able to enjoy the Enchanted Tiki Room as Walt intended it (there's no annoying Iago overlay here) - plus you can get a Dole Whip right there, and take it into the show with you

, if you are a DW kind of person. (Can you tell I am?)
If you want some ice cream later in the day, avoid the Gibson Girl parlor on the west side of Main Street, and instead enjoy a much shorter line at the Cone Shop at the end of Center Street on the east side of the street.
Both POTC and IASW are both longer and better at DL. Be sure to check them out for their individual differences. And the Mansion - wow - the facade is phenomenal, and you enter from the front, not underneath the side as at WDW. (Did you know that the HM was the 1st attraction completed at WDW back in 1970, because when they were building the HM for DL in 69, they built a 2nd set of the sets and props at the same time - for the MK?) Plus both POTC and the HM move you underground and beyond the berm (whereas the MK's versions don't) - so that stretching room is actually moving down at DL (unlike the MK's where the floor stays put but the ceiling goes up). You'll notice here the original portrait corridor too, that the recent upgrades at the MK added in after the Doom Buggy load area.
And be sure to enjoy Magical (the fireworks) and see Dumbo fly!
CA Adventure has a lot of cool stuff too, but a lot of it is very similar to what you'll find in different places in FL. WOC of course is the newest addition. Toy Story Midway Mania does NOT have a FP line - so prepare to stand in line if you really must go on it. While the queue is different of course, the attraction is the same as in FL. Mulholland Madness, the Silly Symphony Swings, Mickey's Fun Wheel, California Screamin', the Maliboomer and the Goldyn Zephyr are all unique to CA. Definitely be sure to use the GCV private entrance in the morning into DCA to get your WOC FP's. They let resort guests in earlier than non-resort guests - so be sure to ask about that at check-in.
The villas are fabulous - and you will LOVE the proximity to everything at the DLR. Can't wait to get back there this fall and Christmas.
Have a wonderful time!