Originally posted by jtbdas
Keith,
The simplest and most direct route is to take I-75 South to the Florida Turnpike (which has tolls, but worth it), continue South on the FL Turnpike to Osceola Parkway, take Osceola Parkway West (right when coming from the north) and it ends inside Disney Property, if you are staying on Property this is your best bet, however if you are staying off property you may want to use the I-4 West exit from the Turnpike depending on where you are staying. Either one of those exits will get you there accordingly.
Hope this has helped.