It's a pretty straight shot on the Florida Turnpike (or "Florida's Turnpike" as it is more properly known). Sure there are tolls and all, but those of us from the NorthEast are used to that, aren't we. It's a fairly pretty road actually and you can roar down it at 75 and still be within the speed limit. Plus the rest areas are worth stopping at, very clean and with services you might actually want to use (not at all like the Mass Pike).
We actually got us a SunPass, the FL equivalent to our EZ Pass up here. I did have to pay a $25 deposit and have to call in my license plate number from the rental car for them to keep on file, but since I am saving a little on tolls and I don't have to stop, it's worth it for us. We are DVC members and AP holders so we're down a couple of times a year. Plus next month we're at a conference in Miami Beach, then on to Vero and finally a couple of WDW days - so plenty of FL tolls ahead of us in the coming month.