I hope I don't come off wrong, but this might be easier to answer if you said where you were driving from.
We drove from NY for the first time this year & it was a piece of cake. No men needed.

From NY it's a straight run, but like I said, I don't know where you're starting from. We were so ambitious we drove straight through, with no stopovers! Btw, that was not a good idea unless you want to arrive like this

! LOL!
If you or anyone you knows belongs to
AAA, request a trip tik, it has useful info on it, like gas station stops. They'll even send maps & tour books if you request it.
We did a lot of the suggestions already mentioned. We found the cooler w/ small plastic bottles of water, Coca-Cola, sandwiches, healthy snacks a good idea. Antibacterial wipes came in handy, especially w/ all those self serve gas stations. Plenty of good music kept us going!
A car pillow & blanket were extra nice comforts. We kept a flash light in the glove compartment for map reading during night driving. We liked to keep track of where we were. But the roads were well marked. We encountered a lot of construction & bad roads, but that was just a nuisance, not a deterent.
I'm not sure how fast you're used to driving, but the speed limit is fast! A word to the wise, if you're not used to the speed, move over to the right & let the "Brother Truckers" pass!
Best of luck! Remember the pioneer women made it all across this great land, & they didn't have power steering, A/C, or cd players!
Have a fun, great, safe trip!
