We are from Charlotte, NC and take 77 to 26 through Columbia, then 95 to 4. We like to stop in St. Augustine at Comfort Suites at World Golf Village (great free breakfast and can sleep up to 6 in some rooms!) Before getting to St. Augustine we stop at the Chick-fil-A in Pooler, GA (exit 104 off I-95) on the way down to give the girls (6 and 4) a chance to play and burn off some energy. When we leave disney

we know the girls are completely worn out and can make the trip all the way back with usually just 2 stops. We stop in St. Augustine on the way down simply because we never know exactly what time we will be leaving with DHs schedule and we are more rested to start our vacation. We are suprising the girls during our November trip with the
MVMCP. We leave sometime Thursday afternoon, drive down to St. Augustine, then Friday morning we get up and have just a couple more hours to drive and can roam the resort before heading over to MK for MVMCP.
PP stated dvd's are a must. Plus, we pack special new toys, coloring books, new crayons, and glow sticks just for the drive.
Funny story...On our very first trip to Disney we were less than a mile from home, stopped to fill up the gas tank, went to put in Toy Story and our vcr/dvd player decided that it didn't want to work anymore.
To our surprise the girls did great the whole trip down and back. They were 3 and 18 months. I think we were all "too excited" that it didn't matter.