Thank you for the offer! I'll take you up on it! We've tried taking 301 - but that was also a mess through Virginia. My DH always thinks it takes longer to take the ferry - but I think it is probably the way to go! Thanks!
Oh, man, I did 301 once just trying to get to Richmond.
The ferry way is longer if you can

I 95 and have no traffic. So, your dh is right! However, if you like to keep moving while driving, we really find it a fun ride. And, given the number of Quebec, NY and NJ plates we see doing the same thing, we must not be the only ones.

Here's the route:
Exit the ferry terminal in Lewes, DE by bearing right (all traffic does) and turn left onto Rt. 9 (comes up fast -- most folks are doing the same thing). Then, turn left onto Rt. 1 towards Rehoboth, and stay in the right lane. Go approx. 1 mile, and turn right onto Rt. 24. You will be heading SW towards Millsboro, DE. The first few miles getting off the ferry can be thick with traffic. Sometimes along Rt. 24, you can find good gas prices. If you see some now, take advantage. Never had better luck with gas prices as we get farther down the Delmarva Peninsula.
Travel Rt. 24 for approx. 15 mi., and look for a left turn for Rt.
113. After turning left onto Rt. 113, you'll be heading south. You will cross into MD at Pocomoke City, and join up with Rt. 13. Take Rt. 13 South across the Chesapeake Bay Bridge-Tunnel, which is a pretty cool thing to do. There's even a rest area on the expanse of the Bay Bridge-Tunnel.

After crossing, you'll be on Rt. 13 in Va Beach...and there are some traffic lights (and a Wawa on the left!).
From Rt. 13, take I-64 towards Chesapeake/Suffolk. Whatever you do, head towards Suffolk. The roads in this area are confusing, so whoever isn't driving needs to co-pilot to help read the signage and match up with the directions. Keep going
past Exit 297 and then follow signs for I664/Rt. 58/Rt. 13/Rt.460/Suffolk. You want Rt. 13 and then Rt. 58, so don't stay on I-664. Follow Rt. 58 West across the "bottom" of Virginia to Emporia, VA, where you'll pick up I-95 South and almost be in NC. It takes roughly 1 hour to get from Suffolk to Emporia.
Notes -- Ferry ride- plan for 2-2.5 hours (wait/embark/crossing/disembark). You can probably plan for closer to 2 hours as you are close enough to be able to time the wait to be minimal (get there right around the 1/2 hour prior to sailing). There are a few lights on Rt. 24 and Rt. 13 each. Speed limits are 50ish all through there, higher on Rt. 113, which is more like a limited access highway (though not). HTH.