Yes, we take I-75 and in Florida we get on the turnpike. There's a part of the turnpike that gets very close to I-95 at I believe Ft. Pierce and sometimes we cross over to I-95.
Just returned from there and go quite often as I have a house in Pompano Beach. It depends where you are leaving from. I live in the Toronto area and prefer to go through Buffalo the I90/I79/I77 route. From Paris, I'd take the 403 to the QEW to Buffalo. You are looking at about 22 hours driving time.