It's very hard to know. It really depends on how many people are checking out early the day you are checking in, the housekeeping schedule and the room assignments.
In our experience, not really. In 16 years of DVC use we have checked in on every day of the week. Sometimes the room is ready, sometimes not, but it doesn't seem to hinge on the day of the week. We've had a room ready after a full night in busy season and we've had to wait when checking in on a Friday in slow season. It really is hit or miss.