I *hate* leaving my boys, even for work. I might be going cross-country for a month after the baby is born and I'm debating ways to take the kitties with us. They'll have so much disruption in their life in the next week or so - I don't want them to think Momma abandoned them, too!
We leave Ted with my parents, where he loves to be. As a matter-of-fact, there are times when I think he's sad when we come home!
It sure does make it easier to come home from WDW though. I hate to leave there but I am relieved to go home to "my girls."
But, when we usually go away I board Mickey at the vets cause it's usually time for his checkup anyway. However, everytime I leave him I cry. I even tell the girl that I have to check him in and give them all the info they need before they actually take him away from me because I'll cry 
I hate to think about it as it breaks my heart!