Driving is about 45 minutes to Hollywood and 90 minutes to SD. SD is an easy drive b/c you're right of the main freeway (5) at DL. Hop on it and head South and it'll take you straight to SD. We just did this trip in the fall but stayed off-site in Anaheim. We also stayed a few nights in SD. We really enjoyed SD. It's beautiful & the zoo is fabulous.
Sights we saw and enjoyed:
*Aquarium of the Pacific (half day)
*Santa Monica Pier
*Beaches at Huntington, Newport and Balboa
*LaJolla (if you're animal lovers, check out the harbour seals that come onshore at "Children's Pool" in LaJolla)
*Hollywood attractions
The only thing we did that we would advise to skip was the LaBrea Tar Pits, and that's with my dh being a Geological Engineer. It took a half day to do and it wasn't all that exciting.
Not sure where you're from, photomama, but we heard so much about the traffic before we went but traffic we experienced in the LA area was pretty tame compared to the Greater Toronto Area! The only thing to watch for is, if someone is about to hit you, they'll keep going, even if it's their fault and it's up to you to move to avoid being hit! That was a little scary a few times.