It is recommended to not pop the blisters but if they are large I don't know a person who won't pop them.
Keeping it lubricated with the antibiotic ointment/cream should reduce some of the discomfort and it should feel much better in the am as the PP said. Don't mess with the skin unless it is loose. If it is loose it leaves a pathway for bacteria and should be removed but if the blister drains and is just flat it should be fine with the bandaind/cream.