Everyone has their favorites, which depends on what they are looking for in a resort. Are you looking to save money, have the best transportation, nicest pool, etc.? Is this a once in a lifetime trip or do you plan to go back often? Which parks will you spend most of your time (I'm assuming MK since you have young children? Will you have a car? It also depends on how much time you will spend at the resort and if you are going at a time of the year that you will be using the pools a lot.
We've stayed at the Poly, Contemporary, WL, AKL and the Swan. Also at Coronado Springs and I will be staying at Pop with my 4yo. We have 4 children so that influences where we can stay. Before my youngest was born and when he was under 3yo we stayed at the deluxes because we could all fit in one room. We didn't mind sharing the bathroom and liked what the deluxes had to offer as far as transportation and nice pools. This next visit I didn't want to spend a lot since it is a bonus trip for my 4yo and myself. Next January we hope to go back to WDW as a family and will probably stay at a value or mod because we will need two rooms (or maybe at the cabins).
You really can't go wrong and I think splitting a stay between two resorts is a great way to try out different resorts.
T&B