We remodeled 3 in our house. Things to think about:
ADA access. We were young and fit. Twelve years later I had a knee replacement and I couldn't get my walker over the lip into our shower, or the walker thru the door to the toilet. If we stay in this house, we'll redo our master bath to have a no-lip walk in shower and wider doors.
Do you really need the tub? I don't take baths, ever. We took out 2 bathtubs and put walk in showers there, but left one tub in the girls' bathroom.
What kind of water do you have? Ours is very hard so fancy fixtures just get gunked up with deposits in a few years.
Shower head - I picked one for my son's bathroom that only has water coming out in a cone, nothing in the center. Total PITA! Washing your hair in it requires circling your head to hit the water. Now I know to look at how the water is distributed thru the head.
Ease of cleaning - those waterfall type faucets are pretty, but the flat area gets dirty and for us builds up more hard water deposits. Glass sinks also get yucky looking really fast and you can't scrub them as hard as porcelain. Tile grout gets dirty. Get a neutral color that won't show dirt or mold easily. Bigger tile, less grout lines. I love my granite counter tops, but the girls' bathroom has a single piece molded counter with two sinks. Also easy to clean and looks good with the cabinets we chose.
Counter space - how much do you want? We got a great sink from Overstock.com for ds's bathroom. He has a tiny counter so we found a "bowl" type vessel sink that has a very narrow bottom, almost like a cone. That left way more space for his tooth brush, soap, etc.
You can "upgrade" your look with just adding accents of fancy tile. We have a vertical strip of a really pretty narrow tile with glass tile inserts in the shower and another on the wall in front of the shower. The vast majority of the tile is standard large squares.
You can also "upgrade" the look of the cabinet hardware by have a few accent, more expensive, pulls but not do the whole cabinetry with them.