We took our 33' TT down in February '02. We will also be driving down when we go this April. Our first trip, we had myself and my DH, DD, DS, Grandpa and his gf. We have an F250 crew cab which very comfortably seats 6. This year we are taking my mother, so there will only be two of us in the front.
My husband has logged well over 2 million miles as a long distance truck driver (now only working locally), and has no problems with the drive. We take a straight shot down from NE Mass, 1300 or so miles, about 22 hours. We will leave on Thursday evening, stop just outside of NJ in a rest area or truck stop to sleep for the evening, then stop again Friday evening around Georgia, arriving at FW Saturday morning. We then spend 5 days before leaving Friday morning to come home. That will leave us all day Sunday to recuperate.
What will be nice about this trip is that hopefully in the next 5-6 weeks, the weather will warm up enough to put some water in the tanks so we can at least use the toilets and wash up in the bathrooms without having to use the rest areas when we get up in the mornings. When we went in Feb. '02 we had to leave the trailer winterized until we arrived in FL.
You can go down and go over the GW bridge without any problems if you time it right. Going around DC isn't a chore either. You can go around DC without adding any time to your trip.
What is nice with DH having travelled all over the country for 30+ years, is if we encounter traffic, he usually knows away to go around without getting lost or having to ask for directions

We all know how men hate to do that. Certainly mean no offense to the men. Just a little joke.
Melissa