I've been to the House of Blues Sunday brunch (it's great by the way!) and to Boatwright's. While both are restaurants I can recommend, my guess is that neither will satisfy a Southern's yen for real Southern fried seafood.
I tend to go with the previous posters suggestion to just look at my time at WDW as a dining experience. I'm from Alabama, I can have real Southern cooking anytime....at any number of restaurants near me or at my own house. I've come to love some of the dishes that I most likely would have never tried otherwise.