I posted this question once and got mixed replies. I think, in part, it depends on your park patterns and when you'll be going.
In our case, we'll be going in May, which isn't a super-busy time. And we'll only be going to the park once a day (early) and returning to our resort once a day (usually early afternoon). . . Additionally, we'll be walking to MGM and Epcot, so we'll only take the stroller on busses three days (two MK days, one Animal Kingdom day). So, I think whatever pain the stroller is will be be outweighed by the comfort it provides when we really want it -- as we're really hoping our little one will sleep the two or three days that we're hoping to stay longer at the parks. I figure, we'll have the stroller collapsed and ready to go before we get on the bus, and DH will deal with the stroller. I'll have a backpack and the kids. We don't plan on staying late nights, so they shouldn't be sleeping . . . . It doesn't sound all that bad.
I guess if you were planning on staying late each night and leaving after the shows along with the crowds, it could be really tough. The kids will be exhausted, the busses crowded . . . YOU exhausted!