I took it when I was 30 and I wish I had done it years sooner. I developed severe cystic acne as an adult and I hated it! The only side effect I had of accutane was severely dry eyes and dry lips and to a lesser degree dry skin. I did a lot of research to find the best remedies, so please allow me to make a few suggestions!
1. Aquaphor is the best stuff for dry lips. Most lip balms have ingredients that are proven to cause greater long term dryness. Aquaphor is fantastic and has healing properties. And lucky you, these days you can buy it in small tubes as opposed to the huge six ounce tubes I used to carry with me everywhere! Make sure you purchase at least four tubes. Have one everywhere you go...in your house, at school, at your job, at your bedside, and in your car. The reason why is that if you forget it, you will regret it. It does not take long for accutane lips to dry so much they crack and bleed. You will probably need to have this stuff on your lips at all time. Keep it by your bedside so when you wake up, you can apply it quickly without waking up too much!
2. If dry eyes are a problem, purchase liquid eye drops for daytime use and the ointment for nighttime. I recommend an eyemask so you can keep the ointment in and the air out. Forget about contact lenses while on accutane!
3. Consider Cetaphil lotion for your face and body. It is odor free, has no scent and works very well. I would start using it before you begin the accutane to give your skin a head start! Don't forget to apply it to your feet. And here's another tip; when you get out of the shower, apply the lotion while wet and air dry for about ten minutes. Blot dry with your towel if still wet. The lotion will soak into your skin much better and you will love how soft it makes you. I still do this ten years later!
4. Drink a LOT of water! And avoid stuff that will dehydrate you such as caffeine and especially alcohol.
5. The best time to start accutane is in the fall. The sun is horrible for people on accutane. Also, extreme cold and wind can make dry skin more uncomfortable. I started in September and that worked very well for me. If your house gets dry, use a humidifier or simply boil some water. Just try to keep some moisture in the air!
Some people report that for a period of time, their acne gets much worse before it gets better. This did not happen to me, but it seems to happen to a good many people. Don't let that discourage you! The end result is well worth it.
And one last thing, you will not bounce right back from the dryness after you finish your treatment. I think it took me several weeks. So plan to have to treat dryness for a while after you finish the drug.
Good luck!

I am acne free ten years later with only one treatment...and I wimped out and stopped three weeks early! I love being acne free.
If you ever have any questions, feel free to send me a PM. I learned a lot of tricks to deal with the side effects. It's not very pleasant, but it is worth it!