Actors who had both a successful Drama and Comedy TV series

Steve Carell ~ The Office, The Morning Show

Debra Messing ~ Will & Grace, The Mysteries of Laura

Whoopi Goldberg ~ Star Trek Next Generation, Whoopi
 

You win with Bryan Cranston

Jack Klugman was good too. :thumbsup2 And the actor who played his tech assistant, Sam, also played Number 2 Son, Jimmy, in the old Charlie Chan mystery movies series, as the sidekick relief character.
 
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John Lithgow - Third Rock from the Sun, Dexter

He was so creepy on Dexter that I just can't look at him the same anymore.

Lithgow does a really good job at being the villain. He was also the villain in Ricochet with Denzel Washington and Cliffhanger with Sly Stallone.
 
Here’s a more obscure one: Vernee Watson is currently on Bob Hearts Abishola (comedy) and General Hospital (daytime drama). She’s awesome on both shows!

Max Gail was on Barney Miller and is also on General Hospital. And while we’re at it, so is Carolyn Hennessy (Cougar Town).
 

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