Sure you can do it!! Now I can't remember if your list included having a cell phone and car charger (or a tracfone) -- also remember your phone numbers for family, friends. You can have just as many problems driving around home as on a trip. You can have your auto club (
AAA?) make a map for you of the fastest route, but why not consider making a vacation trip out of the drive? Head for some historical or scenic spots and see some of the country while you're on your way (sounds like you can make your own schedule).
I've done tons of driving alone, and had a couple of flat tires, etc. over the years -- but it's all worked out fine.
There are lots of motion sickness prevention options now, if you want to give more thought to going by train.
If you're an extra cautious driver, you might be better off taking interesting, older highways, instead of freeways (if you're pokey, try to stay in righthand lane as much as you can).
Driving alone, on your own schedule, can be a really fun experience.