Wow... I have only made the Drive (to and from Disney) 3 times. My issues were with traffic more than anything else. Never had an issue at a rest stop. We did stop at one that looked a bit sketchy... took all about 5 seconds and both DW and I agreed that we could wait until the next rest stop.
We have slept in the camper in truck stops and rest stops. Ironically, the one time we stayed at a hotel (our last trip home in August 2016), because it was just too hot to stay in the TT without the AC, we ended up getting our Truck and TT damaged. Sadly we didn't notice the (albeit minor) damage until we got home because we left early and it was still dark outside.
I have to agree If a place or people at at it don't sit right or make me feel funny it's time to go. We did stop for gas one timeat a 7-11 on rt 58 just before I95 that gave us that feel never again. Today with GS trip routing tool I plan fuel stops at Pilot/ Flying J's With our furballs we also try and stop at places we can walk them at
I think that common sense is the biggest rule. Obviously, be aware of your surroundings (whether you are carrying a weapon or not) and have a plann I try to make sure I always have enough gas to get to the NEXT stop if the one I am stopping at has an issue (Can't get the Rig into the pump area, price way to high, or even scary/sketchy locations). Fortunately, I have been pretty successful in not encountering too many issues of concern (again, traffic notwithstanding). Of course my ways aren't always good for others. I don't mind the pulling in to a campground for a night, it's the whole "reservation" thing that's my hang up with it. (timing the 1 night stay with travel plans effectively). Sometimes I make "Good Time" others, I could be way behind...