The only two unique rooms that I'm aware of are the forward 3B rooms 11006 and 11504, which are huge and effectively 1-bedroom oceanview concierge rooms.
Maybe someone could answer about the equivalent aft cabins, if they also act like a suite with a separated bedroom space?
EDIT: looks like the "corner" cabins on most decks have unique floorplans. Like cabin 8006, for instance. Quite a bit more space to spread out, even if the floorplan is a bit of an odd duck. The people that book these cabins probably specifically seek these out because of the extra space.