Another transplant here.

That last winter with black ice made my "moving to Florida" decision for me (1997).
Moved to the south west originally. Family responsibility brought us to the Orlando area. Initially rented about three miles north of Universal. Now live in Winter Garden area.
Rentals are expensive for the most part. Also, apartments are small, and garages are often extra. Make absolutely certain you are in a "good area" before you sign the lease. Absolutely.
Traffic. The greater Orlando area (maybe Florida overall?) does not know how to MERGE!!! Drives me NUTS!!! Tourists are not the only traffic hazard. There are tourist areas that are more hazardous than others, but they cannot be blamed for all the problems. Slow moving traffic is a daily event and people plan their days around those slow moving times.
Orlando, contrary to what you will be told, is not a city. It is a sprawling "town." There are no "districts" no ethnic shopping areas, no "Little anythings" except for the small Little Vietnam on 50 just east of I-4. A great place to go for Asian shopping (food and tailors) and restaurants.
Proximity to WDW. Be prepared to have the excitement and novelty of WDW morph into a comfortable old shoe. We have APs and are DVC owners but WDW is more of a home town place now, than a vacation destination. We vacation elsewhere. WDW is usually weekend visits or short stays over major holidays. It's nice to get comfortable with WDW, but the trade off is the WDW excitement.
Restaurants: Odd. There are all those Disney ones of course, but unless you are willing to plan like a tourist and book your meal weeks ahead, don't plan on walking in. That is long over. Restaurants close to Disney, although offsite, tend to be less dedicated to providing you with a good experience. It's as if they know they are in the heart of the tourist section and don't care about repeat visitors. Not all mind, but enough.
I'd love a good Ethiopian restaurant in the area. Yum! Cuban restaurants are available, but the best are small ones deep in Orlando.
Surprisingly, forget good pizza, good Chinese, and good seafood. Seriously. I've never seen anything like it, but this area is bereft of those three.
I travel a lot for work, and right now I'm in Maryland. Some of the things that struck me: I was stunned by the rudeness of the people.

The grocery shops are basic, with nothing to really recommend them. The prices are quite similar to Florida's. The hills are nice to travel once again. The barns are beautiful. The lack of a decent, non chain place to eat is so disappointing. Cell phone reception is terrible, as is gps service. Now, before anyone gets in an uproar, these are observations, not pronouncements.

I know residents of Maryland love their state just as much as Floridians (natives and transplants) love theirs.
Work: If you are a nurse, come on down! You'll find signup bonuses and nice salaries. Finding employment can take a discouragingly long time. Be prepared.
WDW wages will not keep you in shoes, food and housing (not to mention gas) without help. Several apartment complexes offer discounts to Disney employees. WDW is often criticized for keeping local wages artificially low. I can't speak to that.
It will take you time to get your mind around "summer here is your winter there." By that I mean, here in the summer you don't plan outdoor things. Your AC is on so your energy bill is higher. Thunderstorms ruin the best plans as do winter blizzards. One positive? You know when the hurricane is coming and you can plan for it.
Wildlife: Bugs, bugs and more bugs. Some will get in your house. It is a fact of life as is the monthly pest control bill. Little lizards are a fact of life too. Learn to love them or you will be miserable. If there is a body of unprotected water in Florida, there will be a 'gator in it. This includes your swimming pool. It is ILLEGAL (and breathtakingly stupid to feed a 'gator). There are incredibly beautiful birds here. I saw more hawks, eagles, osprey, and other birds of prey in ONE MONTH of living in Florida than I did in an entire lifetime of living in the north east. Snakes. Some are poisonous. Learn them. Keep away from them. 'Nuff said.
Research, research, research. Do not rely on word of mouth. We'll all do our best to give you our honest opinions, but you have to form your own. To do that you'll need to see and explore for yourselves, and arm yourself with all the information you can gather.
Good luck to you.