The difference is that if you happen to have 3 children, you must have a deluxe savannah room because the regular ones only sleep 4. The deluxe have a daybed. The deluxe are also only located on the 5th floor.
I think that the deluxes are only on the 5th floor too. So if you want to be closer to the animals go with a regular room. We were on the 2nd floor, Zebra Trail, Arusha savannah and loved it.