We have 2 different strategies .. depends on our mood (adventure or future?):
1. Frontier/Adventure lands: WALK (don't run

) to Indiana Jones, grab a FastPass, then ride Jungle Cruise (basically a walk-on that early in the day), then Pirates (still pretty much a walk-on) then back track only slightly to use the Indy FastPass. Then we go grab a Thunder Mtn FastPass (assuming not a walk-on), sprint over to Haunted Mansion to ride, go back to Indy to ride again via the single-rider line, then back to Thunder Mtn to use the FastPass. That's 5 rides, with a double turn at Indy.
2. Tomorrowland: grab a Space Mtn FastPass, go back and ride Star Tours (pretty much a walk-on first thing in the morning cuz everyone else is tearing to Space Mtn), then Astro-Orbiter for the fun of it, then maybe Autopia if the line isn't horrible. Then we'll use the Space Mtn FastPass. Hmmm, that's only 4 rides, I guess ride #5 would be hopping the train to another section of the park....
Our other favorite rides are Splash (grab a FastPass for later in the day while we're over by Haunted Mansion) and Matterhorn (has to FastPass, don't know why, so we time that to hit the line about 5 minutes into a parade time so it's usually a 10 minute wait or less at that point).