we moved to our forever home almost 8 years ago, here's my suggestions-
absolutely look at the house in terms of potential needs as you age-stairs, width of hallways/layout of entries into doors (wheelchair access), layout of bathrooms (if handicapped accessibility is needed down the line is it feasible). are there medical providers locally so you don't have to travel extensively?
if you decorate for the holidays-look at home as far as the layout for that. we lived in a rental home for a year in-between selling and repurchasing-that home had NO place to put a Christmas tree w/out moving some of the large furniture pieces into storage

so it was either a usable living room w/out a tree, or the tree and almost no seating in the living room.
schools-DO NOT BELIEVE SELLERS/REALTOR. call the schools you believe it to be zoned to and confirm (and ask if there are any plans for redistricting in the future)-people repeated sell in our neighborhood and list the wrong district b/c that district has traditionally allowed transfers, a practice that ended this school year. being within walking distance isn't a guarantee-people flocked to buy resale's in our last neighborhood b/c of the new school, what they didn't know was b/c of school of choice there was a multi year wait list.
research homeowner's and auto insurance rates for particular addresses-they can vary greatly within individual cities/towns (you can google search a particular address/street and get crime statistics down to individual police calls). if you get health coverage through an employer, check to see if your premiums (and share of cost/copays) will increase (some employers offer different plans based on where you reside-live outside a certain geographical area and premiums can skyrocket/choices of plans/providers plummet).
is a home that has a particular city as it's mailing address within or outside that city. we live outside the city limits of the city limits-for us that means (1) no city taxes, (2) lower utility rates vs. the monopoly power/garbage/sewage the city operates, (3) lower tax rate on purchases/services (on larger purchases/services, as much as a .6% lower rate makes a HUGE difference).
look to the home on a maintenance basis-are there items you will need that you don't have and will need to budget into purchasing? where we live that's usually some small items like snow shovels, weed sprayers...but inevitably w/in a year new homeowners have also purchased some type of snow removal item like a snow blower/snowblade, mowers/brush cutters (take a peek inside a potential home's garage/shop to see what's there-it might clue you in to what you will want/need for maintenance).
just as you need to look to you aging, look to your kiddos (or future kiddos) aging-what are the middle/high schools like? is there high education if they want to live at home if they go to college? are there accessible activities?
request a utility bill abstract to show how much is annually spent-this can clue you in if a home is not well insulated, if landscaping eats up allot more water than you realize.
as for finances-big down payment is ideal, ideally big enough so you don't have to pay pmi (can add a couple hundred or more to the cost each month). monies set aside for repairs/improvements/maintenance you don't realize until you actually live in the place a while. long term disability, and life insurance (for both employed and non employed spouses) so that god forbid if something happened-there's a way to keep paying the mortgage/living expenses (the cost to hire in the services a stay at home parent provides is much higher than most would anticipate).
as for packing-we started weeding stuff out in advance, but the stuff we weren't sure of we put into boxes marked with a question mark. these were put into the new home in a corner of the garage. any boxes that didn't get opened w/in 1 year got donated (some will say 6 months-we wanted to go through an entire year w/ every season just in case).
as someone else said-STORAGE, STORAGE, STORAGE! make sure there's room for what you have/may acquire so you don't end up having to pay money every month for a storage unit. think not only of seasonal stuff like decorations and yard/home maintenance-but stuff you/kids use part of the year but not others (we've got snow activity stuff next to swimming stuff in our storage space, dd just moved out and there's some boxes of stuff she needs/wants to hang on to for when she has her own place but doesn't need in a shared rental).
if you find a home you REALY LOVE, but there's something you want to change/upgrade down the line-research if it's possible, the cost. in older homes some things are not upgraded b/c the existing is grandfathered into coding laws so replacements entail meeting new codes and extensive/high cost renovations. in newer homes the reason a builder went w/ say electric over gas for kitchen appliances is b/c the cost to do the gas line was/is crazy expensive (and even more so now that the home is fully constructed), an area in the yard that looks ideal to put a play structure, garden, patio on may not have it already b/c of utility or private preexisting easements.