The Missus and I spent a wonderful week in Vancouver in 1995.
We stayed in the west end at a Hotel called The Buchan (
http://www.buchanhotel.com/), which is only a few minutes walk from Stanley Park and Denman street where all of the restaraunts are.
You'll love Vancouver... it is a beautiful city. In addition to Gastown and Canada place, make sure that you get to Granville Island (and the beer IS very good at the brewery

).
Susan and I were big fans of the X-Files at the time, so it was great seeing so many street places where scenes from the show were filmed.
The food is great, the people were friendly.
We spent an additional day/night in Victoria, which was great fun, before taking the ferry to Seattle for a second week of holiday there.
I think you'll ave a great time!
Bill