My mom was born in the north end of boston, i lived in new england my whole life (till i moved to nc 8 yrs ago

) and went to college in boston. we just recently took our kids (8 and 5) to visit family and catch a sox game. here's my advice:
*most of us love tourists, but please don't try to drive around boston proper.

the roads are crowded, unpredictable and other drivers can be impatient

just take the T - it'll get you pretty much everywhere you want to go. go to
www.mbta.com to get familiar w/ the routes and maps. you really don't need a car - i commuted to college every day from 1hr away using the rail and T no problem.
*priceline is fine for hotels. nicer parts of town are copley/prudential, back bay, cambridge, south station, around newbury st. stay away from ruggles/roxbury, chinatown, downtown crossing, and maybe even kenmore sq (all are fine to visit during the day but intimidating at night). we actually stayed in the midtown hotel last april - its not fancy but fine for location and price.
*kids loved the duck tour! lots of good info - go early in your trip and you will learn a lot and be more familiar w/ the way the city is arranged. they have a website:
www.bostonducktours.com
*my son emphatically states that pizzeria regina (in the north end; get off @ haymarket) has the
best pizza he has ever tasted - and he's tasted a lot

the original restaurant is pretty small tho and popular for lunch and dinner - go at an off time like 2p for lunch
*haulocaust memorial really struck my 8yo. eye-opening to read words and stories. I was surprised how much he was touched.
*museum of science must see (green line to science park).

aquarium not bad either although i like the aquarium in atlanta better. children's museum has some interesting stuff. fenuil hall, haymarket/quincy market lots of fun w/ street performers

, shopping, dining. check out fenway park if anyone is into that(get off T at kemore, not fenway right now until they fix the walkways). can take a tour for $20 and get to the historic green monster.
*boston common for swan boat rides and freedom trail as well as lots of other stuff that goes on there weather permitting. the original "cheers" is accross the st on beacon hill if grown ups want to check it out. its actually called the "bull and finch" and its real small, but the food is good and lots of memorabilia from the show.
*there's lots of cruises around the harbor too.
*make sure to check the city website and websites for sports teams that may be playing while you're there. if you want to go see, great, but if you dont you may be frustrated by the crowds.
there's so many tour books out there for boston and there's way too much to see it all. just pick the stuff you're fam is most interested in. sorry so wordy but - love my city! you can pm me if you need specifics.