TPA is 1 hr 15 min to the Irlo Bronson gate, and probably 1.5 hrs to points in WDW (maybe a bit more, as I-4 is perpetually under construction.) Compare to about 40 mins for MCO.
Our rule of thumb is that if we save $200 or more, it is worth it to fly in/out of TPA. Otherwise, we don't bother.