I'm a driving chicken, but made the drive from Orlando to Tampa last month. It was really easy. I found that the highways/roads in Florida (at least in this area) were incredibly well-marked. I never had a problem. Tampa Intnl. is easy to get out of and onto the highway. We left Orlando at about 8:30 on a Sat morning, and reached Tampa Intnl (stayed at a Doubletree Guest Suites just past the airport) about 10:00, driving about 65, since I wasn't familier with the roads. I'll do it again in a heatbeat if a good fare into Tampa comes along.